GLP-1 and PPARγ Drugs Show Direct Brain Insulin-Signaling Effects
Stanford researchers find pioglitazone and liraglutide improve CNS insulin signaling, measured via neuron-derived vesicles in blood.
20 articles
Stanford researchers find pioglitazone and liraglutide improve CNS insulin signaling, measured via neuron-derived vesicles in blood.
A Phase 3 trial investigates whether the GLP-1 drug liraglutide can slow cognitive decline in T2DM patients at elevated Alzheimer's risk.
GLP-1 receptor agonists show early promise for co-occurring substance use and mood disorders by targeting shared brain reward pathways.
A new oral GLP-1 receptor agonist penetrates the brain, restoring astrocyte-neuron metabolic crosstalk disrupted in Alzheimer's disease.
A massive real-world study of 877,000 OSA patients finds GLP-1 receptor agonists dramatically reduce strokes, hospitalizations, and mortality.
A Rutgers study finds GLP-1 users show dramatically weaker links between impulsivity, alcohol use, and violent behavior.
New research tracks the surging use of GLP-1 receptor agonists among adults with obstructive sleep apnea, raising questions about real-world impact.
New NIH research reveals the brain-cell signaling mechanism behind GLP-1 drug plateaus and a potential way to extend their effects.
A study of 100,000 people found semaglutide users had 44% lower depression risk and 42% fewer psychiatric hospitalizations.
New research reveals GLP-1 drugs like Ozempic significantly reduce depression, anxiety, and substance use disorders alongside weight management.
New obesity medications are transforming OSA treatment, but key questions remain about optimal strategies for cardiometabolic risk reduction.
A selective D3 receptor ligand reduces leg movement symptoms and improves sleep quality in a rat model of restless legs syndrome.
Study shows 2'-fucosyllactose improves cognitive function in mice by modulating gut microbiota and brain serotonin levels.
A completed Phase 1/2 pilot trial tested whether the senolytic duo D+Q penetrates the brain in early Alzheimer's disease.
A new study warns that diabetes medications could confound Alzheimer's biomarker studies, distorting our understanding of the diabetes-dementia link.
New research reveals how sleep quality directly impacts glucose control, offering actionable insights for diabetes management.
A Phase 1 trial examines how gadobutrol moves through and exits the bodies of newborns and toddlers undergoing routine contrast MRI.
Study reveals how gestational diabetes significantly impairs sleep quality and shifts circadian rhythms toward evening preference.
New research reveals how melatonin prevents harmful protein aggregation linked to both type 2 diabetes and brain degeneration.
Breakthrough antisense therapy demonstrates sustained benefits for rare genetic form of ALS in extended clinical trial.