20 articles
A µ-opioid receptor superagonist shows strong analgesic potency in preclinical work while minimizing addiction, respiratory depression, and other classic opioid harms.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
SOMCL-668 improved memory and reduced brain damage in Alzheimer's mice by targeting sigma-1 receptors and protective pathways.
Stanford-led framework defines the five core components of medical digital twins and maps how AI plus mechanistic modeling can create living patient simulations.
MIT researchers decode how C. elegans brains coordinate sensory input with motor actions during navigation using sequential neural firing patterns.
Researchers assembled data from 200 studies to map how human brain cortex develops, revealing new insights for neurological health.
Scientists built human amygdala-like brain organoids that model stress circuitry, uncovering a novel cortisol-driven mechanism tied to primate-specific gene regulation.
New research shows Hericium erinaceus can force neuroblastoma cells to differentiate into mature neurons while stopping their cancerous growth.
A 6,000+ organoid study links specific cellular phenotypes to microcephaly, polymicrogyria, epilepsy, and intellectual disability with 92% classification accuracy.
A landmark review reveals the ANS regulates metabolism, immunity, and aging — far beyond simple fight-or-flight control.
A multi-omics subspace-merging algorithm identifies biologically distinct AD subtypes, pointing toward personalized treatment strategies.
Researchers mapped a conserved molecular signature in motor neurons that emerges before cell death in ALS, pointing to new therapeutic targets.
A molecular atlas of the mouse olfactory system reveals how social odor signals are spatially organized from nose to brain.
Boosting BNIP3 in muscle tissue extends fly lifespan and shields the brain from age-related degeneration via a muscle-brain signaling axis.
Comprehensive review of 2021-2025 proteomics reveals 866 consensus protein changes and novel therapeutic targets in Alzheimer's disease.
Novel body-based therapy increased oxytocin levels by 46% and reduced psychological distress in medical professionals.
New nanopore sensors could transform how we monitor neurotransmitters in real-time, opening doors for precision brain health interventions.
Scientists use brain organoids to capture individual differences in brain development, offering new insights into neurological health.
A GeneReviews update details how activating MTOR variants cause a rare overgrowth-intellectual disability syndrome, with early rapamycin trials showing promise.
New research reveals that gene therapy for SMA causes significant immune activation, suggesting immune dysfunction is central to the disease.
