20 articles
Yale researchers unveil two spatial sequencing methods that simultaneously map gene expression and epigenomic state within intact tissue sections at near single-cell resolution.
Researchers identify global patterns of gene expression changes during aging and develop predictive biomarkers across different human tissues.
Perturb-FISH combines CRISPR screening with spatial gene mapping to reveal how cells communicate and respond to genetic changes.
Scientists develop method to map three types of brain molecules simultaneously, revealing metabolic changes in neurodegeneration.
New technique simultaneously tracks cell division and gene activity in living tissues, revealing hidden repair mechanisms.
A 38-plex imaging study reveals how microglia shift along a continuous activation spectrum in Alzheimer's disease, with key protein changes in CA1.
A massive multi-species transcriptomic study reveals conserved molecular hallmarks of aging and mortality, uncovering modular architecture linking inflammation, mitochondria, and chromatin.
A new nanopore-based approach aims to sequence peptides by reversing the translation process, potentially transforming proteomics.
Researchers identify four senescence-enriched vascular cell clusters in atherosclerotic mouse aortas and derive a conserved transcriptomic signature including Spp1, Ctsb, and Tnfrsf11b.
Comprehensive review of emerging single-cell technologies that simultaneously analyze DNA, RNA, and proteins from individual cells, revolutionizing cancer diagnosis and treatment.
Revolutionary technique sequences individual protein molecules by converting them to DNA, enabling precise protein analysis.
A landmark NIH-funded consortium is building the first reference atlas of somatic mutations across healthy human tissues to decode aging and disease.
Revolutionary pathology technique reveals how diseases spread and interact across different tissues in unprecedented detail.
New spatial mapping reveals how gene therapy vectors differently affect male and female liver function and metabolism.
A sweeping 8-omics study of 322 healthy adults finds ethnicity, geography, and diet drive profound molecular differences — including biological age.
Scientists discover muscle cells bypass normal nuclear pores to export oversized RNA transcripts via a newly identified budding pathway.
A landmark study integrating genome, methylome, transcriptome, and proteome data from 1,000+ participants reveals five master exercise genes in muscle.
GlycanDIA workflow enables precise detection of low-abundance glycans, uncovering distinct RNA glycosylation patterns.
A landmark mouse proteome atlas across 32 tissues reveals how the circadian clock controls protein expression in space and time.
Researchers mapped every cell type across fruit fly development, revealing key genes that control how cells differentiate into specialized tissues.
