20 articles
Super-resolution microscopy reveals how mitochondrial mRNAs are distributed, folded, and released during apoptosis inside living cells.
Researchers discover unique molecular patterns in lipedema patients and develop predictive models for this poorly understood condition affecting women.
FTO demethylase in AgRP neurons alters Kif1a splicing to boost neuropeptide release, promoting weight gain in mice.
Finnish study identifies distinct metabolic signatures for different genetic diabetes risk patterns, opening doors to personalized prevention.
A 6-month AI-driven personalized diet intervention cut BMI by 33% and reduced biological age by 8 years in morbidly obese patients.
Scientists developed a comprehensive genetic risk score that outperforms existing tests for predicting metabolic diseases across all ethnicities.
New research reveals genetic factors that determine individual responses to weight-loss medications like semaglutide.
Scientists identify how different immune cells use specific nutrient transporters, revealing new targets for autoimmune diseases.
New research reveals how SEC16B protein regulates glucose homeostasis by controlling insulin secretion in pancreatic beta cells.
A Phase 2 trial tests a GalNAc-conjugated antisense therapy in familial partial lipodystrophy patients with dangerously high triglycerides.
New findings suggest genetic variants could explain why some patients lose more weight on semaglutide or tirzepatide โ and why others suffer more side effects.
Large NHANES study reveals metabolic syndrome causes measurable acceleration in epigenetic aging clocks, offering new targets for intervention.
Master the advanced molecular architecture of AMPK โ from isoform-specific signaling and spatial compartmentalization to emerging pharmacological strategies targeting the energy sensor at the heart of longevity biology.
Transcriptomic analysis of Pseudomonas nitroreducens TX1 identifies 241 differentially expressed genes during surfactant degradation.
A novel conjugate merges GLP-1/GIP incretin signaling with pan-PPAR activation in one molecule, potentially revolutionizing metabolic therapy.
Deep dive into the master regulatory pathways controlling mitochondrial biogenesis, quality control, and cellular energy homeostasis through PGC-1ฮฑ coordination.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions โ for those who want the full mechanistic picture.
New research reveals how glucose metabolism directly controls fat tissue expansion through a novel epigenetic pathway involving JMJD1A.
176-person study explored personalized responses to refined carbs, whole grains, and intermittent fasting for optimal glucose control.
New genetic analysis reveals how brain and fat tissue work together to regulate obesity and cardiovascular health.
