20 articles
Yale researchers unveil two spatial sequencing methods that simultaneously map gene expression and epigenomic state within intact tissue sections at near single-cell resolution.
Researchers identify global patterns of gene expression changes during aging and develop predictive biomarkers across different human tissues.
Perturb-FISH combines CRISPR screening with spatial gene mapping to reveal how cells communicate and respond to genetic changes.
Scientists develop method to map three types of brain molecules simultaneously, revealing metabolic changes in neurodegeneration.
A 38-plex imaging study reveals how microglia shift along a continuous activation spectrum in Alzheimer's disease, with key protein changes in CA1.
A massive multi-species transcriptomic study reveals conserved molecular hallmarks of aging and mortality, uncovering modular architecture linking inflammation, mitochondria, and chromatin.
Researchers identify four senescence-enriched vascular cell clusters in atherosclerotic mouse aortas and derive a conserved transcriptomic signature including Spp1, Ctsb, and Tnfrsf11b.
A landmark NIH-funded consortium is building the first reference atlas of somatic mutations across healthy human tissues to decode aging and disease.
A sweeping 8-omics study of 322 healthy adults finds ethnicity, geography, and diet drive profound molecular differences — including biological age.
A landmark study integrating genome, methylome, transcriptome, and proteome data from 1,000+ participants reveals five master exercise genes in muscle.
GlycanDIA workflow enables precise detection of low-abundance glycans, uncovering distinct RNA glycosylation patterns.
A landmark mouse proteome atlas across 32 tissues reveals how the circadian clock controls protein expression in space and time.
Researchers mapped every cell type across fruit fly development, revealing key genes that control how cells differentiate into specialized tissues.
Single-cell and spatial transcriptomics reveal how intratumoral tertiary lymphoid structures shape gastric cancer prognosis and immunotherapy outcomes.
New methods allow researchers to test thousands of genes simultaneously in living mice, accelerating discovery of genetic factors in health and disease.
A landmark single-cell study reveals how gene expression and somatic mutations shift across every major brain cell type from birth to centenarian age.
Computer vision applied to citizen science data uncovers how warm-season grasses adapt flowering time across latitudes, with implications for ecological genomics.
Rockefeller scientists mapped epigenomic aging across 7M cells in 21 tissues, uncovering coordinated, program-like shifts that may unlock new therapies.
Researchers create detailed spatial atlas revealing cellular changes in aging breast tissue using advanced mapping technology.
A multi-method bioinformatics study pinpoints MAX, MLEC, and TMEM59 as key N-glycosylation-linked diagnostic markers for early Alzheimer's detection.
