20 articles
New technique maps thousands of neural connections simultaneously, potentially revolutionizing understanding of brain aging and disease.
A multi-omics subspace-merging algorithm identifies biologically distinct AD subtypes, pointing toward personalized treatment strategies.
A landmark multi-omic atlas of 100 GBM patients uncovers four malignant cellular communities and new therapeutic targets.
A molecular atlas of the mouse olfactory system reveals how social odor signals are spatially organized from nose to brain.
IRISeq maps gene expression across aging mouse brains, finding lymphocytes fuel neuroinflammation and accelerate cellular aging.
A multi-omics analysis of over 1 million brain cells reveals how neurotransmitter systems change across aging and eight neuropsychiatric disorders.
Combining polygenic and transcriptional risk scores from blood raises Alzheimer's detection accuracy, offering a less invasive screening path.
Researchers used genetic data to predict protein levels and identify biomarkers for antidepressant treatment outcomes in 3,559 patients.
A spatial proteomics platform profiled 700,000+ brain cells, identifying a microglial subset that clusters around amyloid-ฮฒ plaques in Alzheimer's disease.
Researchers argue polygenic scores offer a powerful new lens for understanding the genetic architecture of sleep traits.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
A chromatin-remodeling gene called SMARCAD1 controls tau levels โ and switching it off could be a new therapeutic target for Alzheimer's.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
New brain imaging study maps how structure-function coupling fluctuates over time, revealing emotion-linked networks and genetic patterns.
A 6,000+ organoid study links specific cellular phenotypes to microcephaly, polymicrogyria, epilepsy, and intellectual disability with 92% classification accuracy.
Researchers assembled data from 200 studies to map how human brain cortex develops, revealing new insights for neurological health.
Researchers matched fMRI patterns across mouse models and 1,976 humans to find autism splits into hypo- and hyperconnectivity subtypes with distinct biology.
New AI system reveals how genes control each other in Alzheimer's brains, uncovering potential treatment targets.
Comprehensive review of 2021-2025 proteomics reveals 866 consensus protein changes and novel therapeutic targets in Alzheimer's disease.
A Harvard-developed digital seed amplification assay can precisely quantify TDP-43 protein aggregates in CSF, offering a potential diagnostic breakthrough for frontotemporal dementia.
