20 articles
RSL3-induced ferroptosis degrades SHP2 via chaperone-mediated autophagy, amplifying IFN-γ/STAT1 signaling and enhancing anti-PD-1 immunotherapy efficacy.
PQQ, a widely available dietary supplement, inhibits EZH2 and suppresses B-cell lymphoma proliferation in lab studies.
Widely-used anesthetic triggers immune system to attack tumors and enhances checkpoint inhibitor therapy effectiveness.
New study reveals how blocking ribosome production makes cancer cells vulnerable to ferroptosis, an iron-dependent cell death pathway.
New research reveals how a specific protein causes anemia in myelodysplastic syndromes and predicts treatment response.
Inhibiting the mitophagy kinase PINK1 amplifies mitochondrial ROS, activating a BAX-caspase-GSDME cascade that destroys neuroblastoma cells via pyroptosis.
Novel nanoplatform delivers copper and iron ions to trigger both ferroptosis and cuproptosis in cancer cells.
Pyrroloquinoline quinone has demonstrated anticancer activity in preclinical studies, but human cancer trials remain absent. Here's where the science stands.
New research reveals how hepatoma cells evade immunotherapy by secreting N1-acetylspermidine to suppress immune function.
New research reveals how RBM39 protein enhances DNA repair in liver cancer cells, suggesting combination therapy targets.
A newly discovered hepatic micropeptide suppresses liver cancer progression by jamming a key mitochondrial RNA processing complex.
Science Translational Medicine publishes an erratum for a 2024 study on GDP-mannose and antitumor immunity in triple-negative breast cancer.
Researchers discover how SIRT6 protein overcomes temozolomide resistance in deadly brain cancer by modifying histone lactylation patterns.
New research reveals how selenium deficiency drives liver cancer progression through neutrophil aging and immune suppression.
Metabolite supplement protects heart from chemo toxicity and enhances tumor suppression in breakthrough dual-action study.
New research reveals how cancer radiation treatment causes muscle weakness through a previously unknown tumor-muscle communication pathway.
Cancer cells that downregulate SMC4 enter a low-proliferation, diapause-like state that resists standard chemotherapy, revealing a dangerous survival mechanism.
Sequential CDK4/6 inhibitor treatment before anti-PD-1 therapy enhances immune response and tumor control in head and neck cancer models.
Scientists uncover how SCRN1 blocks ferroptosis in liver cancer, revealing new targets for treating drug-resistant hepatocellular carcinoma.
Cambridge scientists engineer a nanoprobe that detects therapy-induced senescence non-invasively through a simple urine colorimetric test.
