Stem Cell-Derived Hepatocytes Could Replace Liver Transplants
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
20 articles
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
A landmark review maps the three pillars of modern lineage tracing and how they're reshaping our understanding of cell fate decisions.
New review explores how 3D organoids and bioengineered niches are revolutionizing tumor research and treatment development.
A major review in Nature Medicine explores how CAR cell therapies may achieve deep immune 'reset' in autoimmune diseases by depleting pathogenic B cells.
New review reveals how advanced genomics tools are revolutionizing cancer diagnosis and therapy development.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity โ not just cell diversity โ as the core therapeutic target.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
Expert reviews compare leading senolytic and NAD+ supplement brands on ingredients, evidence quality, and value.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
New computational advances help identify which tumor peptides trigger immune responses, potentially revolutionizing personalized cancer therapy.
A new review reveals how epithelial-to-mesenchymal transition fuels tumor invasion, immune evasion, and drug resistance through dynamic, reversible states.
Virtual patient replicas built from multimodal data may slash trial costs, generate synthetic control arms, and predict treatment response in IBD.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
A head-to-head review of 10 CGM devices for healthy adults, weighing real-world accuracy data against limited longevity evidence.
A landmark review reframes astrocytes as multilayered processing units that regulate synapses, circuits, and brain function at multiple spatial scales.
A Dana-Farber review maps the path for personalized cancer vaccines โ pinpointing which tumors, timing, and combination strategies will matter most.
A Cochrane review of 4 RCTs finds no reliable evidence that adding endovascular stenting to medical therapy prevents stroke or death in vertebral artery stenosis.