20 articles
Natural flavonoid fisetin activates mitophagy and xenophagy pathways to restrict intracellular Salmonella growth in immune cells.
New research reveals how immune cells use cysteine for both antioxidant defense and energy production, with major implications for cancer treatment.
New research reveals how SIRT2 regulates T cell responses, potentially improving cancer immunotherapy and immune function.
Dying cancer cells release GPX4 protein that prevents immune system activation, revealing new immunotherapy targets.
New research reveals how metabolic molecules function as signaling agents that control immune responses within tumors.
Researchers identify protein stress as key factor limiting natural killer cell survival in cancer treatment.
Researchers modified NK and T cells with special receptors that help them track down and infiltrate solid tumors more effectively.
Researchers identify how TSLP protein creates regulatory T cells that suppress immune responses in melanoma.
Pyruvate, a core metabolic molecule, suppresses interferon signaling by directly modifying STAT1 — linking metabolism to immune control.
New research reveals how IL-35 therapy prevents neutrophil trap formation, offering hope for cigarette smoke-worsened asthma.
New research identifies Lp-PLA2 enzyme as therapeutic target for deadly lung disease affecting millions of workers worldwide.
Researchers identify the molecular mechanism controlling STING protein trafficking, revealing new targets for cancer immunotherapy.
New research reveals how removing ZFP148 protein boosts CD8+ T cells' cancer-fighting ability and improves immunotherapy response.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
A runaway immune response — not the pathogen itself — drives citrus greening disease, echoing autoimmune mechanisms seen in human illness.
New research reveals how immune cells in tumors can both fight and fuel cancer growth, opening paths to better therapies.
Demethyleneberberine, derived from traditional Chinese medicine, significantly reduced lung scarring by targeting NLRP3 inflammasome and EMT in mice.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
Scientists discover serotonin's role in making cancer treatments less effective, opening new therapeutic possibilities.
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
