20 articles
New research reveals FGF21 has a physiological role in reducing ER stress by amplifying the unfolded protein response through sulfide signaling.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Scientists discover how FGF21 fights liver disease through a key protein, opening new treatment paths for metabolic dysfunction.
New research reveals how maltol, a widely used food flavoring, may weaken bones in diabetic patients by disrupting bone remodeling.
Daily anthocyanin supplementation helped over half of prediabetic participants return to normal glucose tolerance in just 12 weeks.
Discover how sirtuins act as your cellular repair crew and learn practical ways to boost these powerful longevity proteins naturally.
A steroid hormone activates receptor GPR56 to block ferroptosis, a form of iron-driven cell death linked to liver disease.
Blocking mTOR forces cancer cells to rewire cholesterol uptake and transport, revealing new drug targets when combined with rapamycin.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions โ for those who want the full mechanistic picture.
New study reveals how the diabetes drug dapagliflozin dramatically alters fat metabolism and kidney function through previously unknown pathways.
Ketone body ฮฒ-OHB prevents sepsis-induced liver damage by modifying antioxidant enzyme SOD2, offering new therapeutic approach.
Explore how sirtuins use NAD+ as a molecular switch to regulate aging, DNA repair, and metabolism โ and what happens when this system breaks down.
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
Diabetes drugs like empagliflozin show surprising anti-aging effects โ mimicking caloric restriction and reducing senescent cell burden.
New rare sugar sweetener may reduce body fat and blood sugar, but research shows mixed results and potential digestive issues.
Two bacterial proteins that sense sulfur compounds unexpectedly regulate nitrate removal, revealing new targets for optimizing wastewater treatment.
Sodium propionate reduced liver inflammation and fat accumulation in diabetic mice fed high-fat, AGE-rich diets through multiple protective mechanisms.
Transcriptomic analysis of Pseudomonas nitroreducens TX1 identifies 241 differentially expressed genes during surfactant degradation.
Breakthrough study reveals sepiapterin dramatically outperforms existing PKU therapy, offering hope for better metabolic control.
Simple sugar supplement dramatically improved diabetes symptoms in mice by stopping inflammatory cells from releasing disease-causing particles.
