20 articles
World-leading expert shares practical guidance on sulforaphane dosing, food sources, and chemoprotective effects in comprehensive Q&A.
Resveratrol targets the USP36-SOD2 mitochondrial axis in gastric cancer, triggering autophagy and ferroptosis to suppress tumor growth.
Scutellarin, a plant-derived compound, shows promise against ovarian cancer by inducing ferroptosis and blocking key survival pathways.
A mechanistic deep-dive into the molecular architecture of redox signaling โ from cysteine oxidation chemistry to therapeutic targeting of NRF2, NADPH oxidases, and mitochondrial ROS in the context of aging.
Network pharmacology and lab experiments reveal CTFs suppress hepatocellular carcinoma via apoptosis, ROS induction, and cell cycle arrest.
A natural plant flavonoid activates the Nrf2/FSP1 pathway to halt ferroptosis triggered by fumonisin B1, a common food contaminant.
A nanoparticle co-delivering sorafenib and an FSP1 inhibitor kills both tumor cells and immunosuppressive macrophages, reviving anti-tumor immunity.
New research reveals how resveratrol blocks pancreatic cancer progression by modifying a key cellular protein through succinylation.
Researchers identify NUF2 as a key driver of prostate cancer and discover fisetin, a natural compound, as a promising inhibitor of this oncogene.
Inhibiting the protein SIRT2 destabilizes a DNA repair guardian, floods tumors with killer T cells, and supercharges immunotherapy in preclinical models.
Natural compound morusin from mulberry makes colorectal cancer cells age rapidly, making them vulnerable to targeted elimination.
A comprehensive review reveals how transsulfuration pathway products and HโS-donors may offer new therapeutic avenues for hyperhomocysteinemia.
A medicinal-chemistry optimized flavonol called F-4N shows 50ร greater senolytic potency than quercetin and resolves lung fibrosis in animal models.
A natural flavonoid from traditional Chinese medicine may combat insulin resistance by inhibiting ferroptosis via the HIF-1ฮฑ/HO-1 signaling pathway.
Natural compound urolithin A significantly inhibits bone cancer cell migration and invasion through AKT1 and MMP pathway modulation.
A comprehensive review reveals fisetin's broad therapeutic potential spanning senescence, neurodegeneration, and cancer โ with key bioavailability hurdles to overcome.
A fasting-mimicking diet activates IFNฮฒ secretion in tumor macrophages by degrading the immune suppressor Trex1 through a NRF1-driven proteasome pathway.
A new review finds kaempferol, a common dietary flavonoid, acts as a senolytic agent and produces dose-dependent hormetic effects tied to aging biology.
A 2026 review evaluates how two common dietary flavonoids target senescent cells, potentially slowing aging and age-related disease.
Pleurotus citrinopileatus extracts suppress inflammation through two distinct pathways in immune cells.
C. elegans study finds all tested pro-longevity compounds extend male lifespan, but sulforaphane and metformin uniquely preserve late-life reproductive function.
