Taurine From Bone Marrow Fuels Aggressive Leukemia Growth
New research reveals how bone marrow cells produce taurine that feeds leukemia stem cells, offering potential therapeutic targets.
20 articles
New research reveals how bone marrow cells produce taurine that feeds leukemia stem cells, offering potential therapeutic targets.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer β and blocking it shrinks tumors in vivo.
Ketogenic diet metabolite enhances CAR T cell metabolism and tumor control in multiple cancer models
Tucatinib-based treatment extends survival from 4.4 to 10 months for women with breast cancer that spread to brain lining.
A comprehensive review reveals how iron-driven cell death can be exploited to treat ATC, one of the most lethal human cancers.
Scientists discover that maintaining proteostasis in tumor-infiltrating lymphocytes prevents exhaustion and boosts immunotherapy outcomes.
Scientists found that inhibiting USP30, a mitochondrial enzyme, restores immune cell function and shrinks tumors in mice.
Redirecting glucose metabolism during T cell expansion dramatically improves cancer immunotherapy effectiveness.
Adding an autophagy inhibitor to anlotinib plus PD-1 blockade dramatically reshapes the tumor microenvironment in NSCLC models.
Scientists discover that enhancing protein cleanup in immune cells prevents exhaustion and dramatically improves cancer immunity.
New research reveals how Ξ±-ketoglutarate regulates AMPK synthesis, offering potential cancer therapy targets through energy stress.
A new strategy combining a TROP2-targeting drug with osimertinib may delay the inevitable resistance that undermines EGFR-mutant lung cancer treatment.
Researchers found that stopping HER2 protein degradation significantly improves trastuzumab deruxtecan cancer treatment outcomes.
Metabolite supplement protects heart from chemo toxicity and enhances tumor suppression in breakthrough dual-action study.
New research reveals how selenium deficiency drives liver cancer progression through neutrophil aging and immune suppression.
Researchers clarify how a clinical-radiological model can guideβand where it falls shortβin managing hepatocellular carcinoma treated with TACE.
Retrospective study of 120 NSCLC patients finds thymalfasin plus chemoimmunotherapy significantly extends PFS and OS without added toxicity.
Researchers developed a new radiotracer that targets cancer cells more effectively when combined with mTOR inhibition therapy.
A macrophage-derived metabolite rewires tumor metabolism and flips immune cells from tumor-promoting to tumor-fighting.
A next-gen RAS inhibitor called daraxonrasib targets KRAS-mutant cholangiocarcinoma, showing strong preclinical results and early clinical activity.