20 articles
New research reveals that targeting a specific toxic protein variant may be more effective than current Huntington's treatments.
A senolytic pairing of dasatinib and quercetin cleared senescent cells at the tendon-bone junction, dramatically improving repair strength in aged rats.
Single-cell sequencing reveals ferroptosis drives pulpitis; thymosin ฮฑ1 restores GPX4, cuts iron overload, and reduces inflammation in cells and rats.
AAV gene therapy successfully restored retinal function and improved vision in rats with LRAT-associated retinitis pigmentosa.
A sweeping review maps every known strategy for delivering therapies directly to mitochondria, from lifestyle habits to nanocarriers and gene editing.
A novel class of ferroptosis inhibitors protects donor organs from ischemia-reperfusion injury, potentially saving thousands of transplant patients annually.
BIIB080 failed its primary endpoint in Phase 2, yet Biogen sees potential signals worth pursuing in the fight against Alzheimer's tau tangles.
Mitochondria-targeted antioxidant polymer shows superior protection against liver transplant injury compared to standard treatments.
Novel biomaterial treatment simultaneously prevents nerve degeneration and promotes regeneration, preserving visual function after optic nerve injury.
Novel nanogel therapy targets mitochondrial ROS to break the inflammation-hypoxia cycle in periodontitis, showing strong preclinical results.
Packaging mitochondria in erythrocyte-derived membranes dramatically improves delivery efficiency, pushing this experimental therapy closer to clinical reality.
Scientists review breakthrough methods for transferring healthy mitochondria into damaged cells to restore cellular energy and combat aging.
Three days of GDF11 infusion post-injury preserved pericytes, protected the blood-spinal cord barrier, and improved functional recovery in mice.
A miniaturized PEMF device failed to raise SpO2 in healthy rats, suggesting COVID-19 benefits may be disease-specific.
First successful gene therapy for aniridia increases retinal thickness and activates key vision pathways in mice.
Novel mineralized collagen scaffold promotes healing of tendon-bone connections across multiple animal models with 82% recovery rate.
Astellas reports encouraging early-stage results for a stem cell-derived treatment targeting age-related eye disease, though data remains limited.
A comprehensive review of pathophysiology, genetics, and emerging therapies for mitochondrial myopathies, spotlighting elamipretide and gene therapy.
Wave Life Sciences shares early trial data on an RNA editing treatment for alpha-1 antitrypsin deficiency, targeting monthly dosing.
Revolutionary delivery system uses microscopic gel capsules to transport healthy mitochondria to damaged heart cells after heart attack.
