ALS Protein TDP43 Controls DNA Repair and May Drive Both Brain Disease and Cancer
Scientists find that TDP43 protein regulates DNA repair systems, linking neurodegeneration to cancer when repair goes wrong.
20 articles
Scientists find that TDP43 protein regulates DNA repair systems, linking neurodegeneration to cancer when repair goes wrong.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
Scientists discover tanycytes help clear toxic tau from the brain. When damaged, these cells may allow Alzheimer's progression.
Scientists discover brain support cells help glioblastoma grow and identify existing HIV drug that could disrupt this deadly communication.
A new tool that boosts mitochondrial activity in neurons restored memory in dementia mice, suggesting energy failure drives Alzheimer's symptoms.
UCLA scientists discover why some neurons resist Alzheimer's better than others, revealing a natural protein cleanup system that could lead to new treatments.
Cambridge researchers found a gene network that shuts off nerve repair โ and an existing hormone drug that reactivates it.
Blocking the protein PTP1B boosted memory and cleared brain plaque in mice, with potential links to diabetes and obesity treatment.
Scientists identify how nitric oxide triggers cellular changes in autism, offering hope for targeted therapies.
Researchers discover TMEM175, a cellular safeguard that prevents toxic buildup linked to Parkinson's when it malfunctions.
Buck Institute finds the longevity-linked APOE2 variant shields neurons from DNA damage and cellular senescence, explaining its Alzheimer's protection.
The SenNet atlas reveals where aging cells accumulate in human tissues, opening new doors for senolytic therapies and healthspan extension.
Stanford researchers found ribosome stalling in aging brain cells triggers faulty proteins and toxic clumps linked to Alzheimer's disease.
UC Riverside researchers show amyloid beta may displace tau from neurons, triggering brain cell breakdown before plaques even form.
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.
New AI system reveals how genes control each other in Alzheimer's brains, uncovering potential treatment targets.
New compounds targeting the cPLA2 enzyme may reduce Alzheimer's-linked brain inflammation, especially in high-risk APOE4 gene carriers.
Baylor scientists find tubulin redirects rogue brain proteins away from toxic aggregates, pointing to a novel neurodegenerative disease strategy.
Researchers turned ordinary brain cells into plaque-clearing machines, reducing Alzheimer's amyloid by half in mice with one treatment.
Researchers discover toxic protein pair that kills brain cells in Alzheimer's and develop compound to block it in mice.