20 articles
A newly identified molecular chain reaction links tau aggregates to neuronal death, revealing ZBP1 as a promising therapeutic target in Alzheimer's disease.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
A chromatin-remodeling gene called SMARCAD1 controls tau levels — and switching it off could be a new therapeutic target for Alzheimer's.
New research reveals how mammalian brains evolved specialized DNA repair mechanisms to support expansion of upper cortical layers.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
A GeneReviews update details how activating MTOR variants cause a rare overgrowth-intellectual disability syndrome, with early rapamycin trials showing promise.
New research identifies ZNF280A as essential for DNA repair and links its deletion to 22q11.2 distal deletion syndrome features.
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
New study identifies KCTD20 gene suppression as a potential therapeutic target for clearing harmful tau proteins in neurodegenerative diseases.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
New brain organoid study shows autophagy-boosting compounds can clear harmful tau proteins and rescue synapses in Alzheimer's disease models.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
A new mechanism links mitochondrial DNA trafficking through lysosomes to gasdermin-driven pyroptosis, with Parkinson's disease genes playing a key role.
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
Scientists discover adult brain cells keep epigenetic memories from development that may fuel gliomas but also enhance regeneration.
Comprehensive review of TSC reveals mTOR inhibitor successes while identifying critical unmet needs in neuropsychiatric care.
Scientists developed mitoDREADD-Gs, a novel tool that restores cognitive function by enhancing mitochondrial activity in mouse models of dementia.
Microglia package healthy mitochondria into vesicles and deliver them to astrocytes, sharply reducing cognitive decline in tau-pathology mice.
New research reveals how context-dependent protein interactions regulate TDP-43 dysfunction in ALS and frontotemporal dementia.
