Muscle Mitochondrial Defects Mapped as Root Cause of Genetic Insulin Resistance
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
20 articles
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
Swiss researchers studied how mTOR protein in fat tissue affects metabolism and insulin function throughout the body.
A completed OSU trial investigates whether short-term exercise training can restore impaired mitochondrial cleanup pathways in overweight and obese skeletal muscle.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
New study reveals how endurance exercise transforms fat-burning brown adipose tissue in just six weeks of training.
A completed University of Michigan trial explored how aerobic exercise training alters RAGE-mediated inflammatory pathways in type 2 diabetic adults.
Carmot Therapeutics tests CT-868, a novel dual incretin receptor agonist, for HbA1c reduction in overweight and obese adults with poorly controlled T2DM.
Small pilot study explored whether platelets could serve as biomarkers for detecting mitochondrial problems linked to diabetes development.
Wake Forest study explores whether the diabetes drug metformin can trigger cellular changes linked to longevity in healthy people.
Study reveals how lean people can still have obesity-like metabolism and whether calorie restriction helps reverse this dangerous condition.
A completed Danish trial investigates how blocking IL-6 signaling with tocilizumab alters fat, glucose, and protein metabolism in humans.
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
Mediterranean diet, resistance training, and diabetes medication combined to combat sarcopenia and improve metabolic health in older adults.
Czech study reveals how strategic fasting and ketogenic diets can reprogram harmful fat production in obesity.
Major study shows lifestyle intervention effectively reverses prediabetes in both African American and Caucasian participants with family diabetes history.
Clinical trial tested whether metformin could enhance resistance training benefits for muscle mass and strength in older adults.
Enanta Pharmaceuticals tests its FXR agonist EDP-305 in a completed Phase 2 randomized trial for non-alcoholic steatohepatitis.
University of Pennsylvania researchers investigated how insulin resistance and testosterone interact in women after menopause.
French study reveals how aging influences metabolic responses to cancer, potentially explaining malnutrition patterns in elderly patients.
Major trial tests whether diabetes drug metformin can prevent frailty syndrome that affects millions of aging adults.