20 articles
Blocking mTOR forces cancer cells to rewire cholesterol uptake and transport, revealing new drug targets when combined with rapamycin.
New research reveals how mitochondrial metabolism regulates dendritic cells' ability to activate anti-tumor immunity.
Mice lacking the HDAC9 gene gained less fat with age, accumulated fewer senescent cells, and showed improved mitochondrial respiration in adipose tissue.
New research reveals how glucose metabolism directly controls fat tissue expansion through a novel epigenetic pathway involving JMJD1A.
Scientists discover how PDAP1 protein reprograms liver cells to burn less fat and make more, driving hepatocellular carcinoma progression.
New cryo-EM structures reveal how LYCHOS protein senses cholesterol levels to regulate mTORC1 signaling, offering drug targets for aging.
A newly discovered lipid recycling loop driven by DGAT enzymes generates significant body heat — and it's been hiding in plain sight.
New research identifies choline kinase alpha as a key driver of diabetic retinopathy and microvascular dysfunction.
A newly identified protein shields the liver from alcohol injury by bridging mitochondria and fat droplets to enhance fatty acid oxidation.
Researchers found a dual-target approach that selectively destroys the most treatment-resistant form of acute myeloid leukemia.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
FTO demethylase in AgRP neurons alters Kif1a splicing to boost neuropeptide release, promoting weight gain in mice.
New research reveals pulsed electromagnetic field therapy selectively enhances ATP-linked mitochondrial respiration, pointing to a specific cellular energy mechanism.
Large NHANES study reveals metabolic syndrome causes measurable acceleration in epigenetic aging clocks, offering new targets for intervention.
New research reveals how the TUG protein traps glucose transporters, contributing to insulin resistance in fat tissue.
Scientists identify an NADH-dependent molecular switch linking glycolysis to mitochondrial ATP synthesis, revealing a new metabolic control point.
Scientists identify how a metabolic enzyme drives kidney inflammation in diabetes, opening doors for targeted therapies.
Scientists discover how FGF21 fights liver disease through a key protein, opening new treatment paths for metabolic dysfunction.
Diabetes drugs like empagliflozin show surprising anti-aging effects — mimicking caloric restriction and reducing senescent cell burden.
Knocking out BNIP3 in macrophages reduced adipose inflammation and improved insulin sensitivity in obese mice, revealing a new therapeutic target.
