20 articles
A major review in Nature Medicine explores how CAR cell therapies may achieve deep immune 'reset' in autoimmune diseases by depleting pathogenic B cells.
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
A landmark 48-RCT Cochrane review finds high-certainty evidence that convalescent plasma does not reduce death in moderate-to-severe COVID-19.
Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.
Bacteriophages transferred during FMT may drive horizontal gene transfer, altering microbial function and antibiotic resistance in ways science has largely ignored.
New computational advances help identify which tumor peptides trigger immune responses, potentially revolutionizing personalized cancer therapy.
A new review reveals how epithelial-to-mesenchymal transition fuels tumor invasion, immune evasion, and drug resistance through dynamic, reversible states.
A new review maps how tirzepatide's dual GIP/GLP-1 action reshapes metabolism across the pancreas, liver, gut, heart, kidneys, and brain.
A new review argues that combining GLP-1 receptor agonists with structured exercise and dietary support preserves muscle and delivers lasting fat loss.
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
A new review links adult cholestasis to pediatric genetic syndromes, opening doors to targeted therapies including novel bile acid transport inhibitors.
A Cochrane review of 21 RCTs finds remote pharmacist care may improve adherence and lower blood pressure in NCD patients.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity — not just cell diversity — as the core therapeutic target.
A Cochrane meta-analysis of 17 RCTs finds blue light TURBT reduces bladder cancer recurrence and progression, especially in intermediate- and high-risk patients.
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A Dana-Farber review maps the path for personalized cancer vaccines — pinpointing which tumors, timing, and combination strategies will matter most.
A systematic review of 90 studies reveals mTOR both drives MS inflammation and is essential for myelin repair — complicating treatment strategies.
A new perspective in Nature Cancer outlines how genetically engineered bacteria can target and destroy tumors from within.
Virtual patient replicas built from multimodal data may slash trial costs, generate synthetic control arms, and predict treatment response in IBD.
A Cochrane review of 4 RCTs finds no reliable evidence that adding endovascular stenting to medical therapy prevents stroke or death in vertebral artery stenosis.
