Why Aging Guts Fail to Heal: Rogue Immune Signals Trap Cells in a Fetal State
Aged mouse colons get stuck in a fetal-like repair mode that makes them hypersensitive to immune attack, derailing gut healing after injury.
20 articles
Aged mouse colons get stuck in a fetal-like repair mode that makes them hypersensitive to immune attack, derailing gut healing after injury.
Age-related shifts in intestinal T cell populations may silently erode gut barrier function, accelerating the chronic inflammation that drives aging diseases.
Bacterial metabolite from flavonoids protects against graft-versus-host disease while preserving anti-cancer effects in stem cell transplants.
New research reveals gut microbes orchestrate a 3-day vitamin A relay from gut cells to immune cells, programming intestinal immunity.
Aging disrupts gut microbiota and mTOR signaling, crippling vaccine responses โ but targeted interventions may reverse this.
New research shows blocking PKM2 in immune cells promotes gut healing in colitis while preventing tumor formation.
Clinical trial tests whether fecal transplants from young, active donors can restore muscle strength and cognitive function in older adults.
Regular physical activity slashes chronic pancreatitis risk and attenuates disease progression via muscle-derived vesicles that quiet pancreatic inflammation.
6-methoxykaempferol from sweet cherries restored immune function by 43% and improved beneficial gut bacteria in immunocompromised mice.
New research questions whether long-term HBIG therapy is necessary after liver transplantation, potentially simplifying post-transplant care.
A landmark review reveals how microbiome disruption before and after stem cell transplants drives deadly graft-versus-host disease.
A Princeton study finds maternal helminth exposure reshapes the microbiome to produce a metabolite that shields offspring from respiratory viruses.
A new review maps the structural and functional changes that help the bowel compensate after resection, and highlights where knowledge gaps remain.
Small study tests synbiotic supplements to combat age-related immune decline in healthy elderly adults.
A 13-year UK analysis of 273 liver transplant patients finds HBIG maintenance may be unnecessary, with NA-only prophylaxis offering a cost-effective alternative.
Researchers develop 22-color flow cytometry to profile unconventional T cells that protect gut health and maintain immune balance.
Fecal microbiota transplants dramatically improved immune checkpoint inhibitor response rates in lung cancer and melanoma patients.
A newly identified microRNA disrupts Paneth cell function in aging intestines, exposing older patients to life-threatening gut complications.
Vaginal microbiota applied to C-section newborns restores a key brain-signaling molecule on skin, improving early neurodevelopment.
Leading researcher reveals how daily movement fights inflammaging - the hidden inflammation accelerating aging.