20 articles
A comprehensive review reveals the thymus retains stem-like epithelial progenitors into adulthood, challenging the idea it is immunologically expendable.
A detailed review of the cellular and molecular pathways driving thymic regeneration after acute damage, with implications for post-treatment immune recovery.
A comprehensive review deconstructs the thymic microenvironment using single-cell technologies, from embryonic formation through age-related involution.
Radioresistant intrathymic stem cells and a secreted growth factor called THGF may hold the key to thymic recovery after irradiation and cancer risk.
Scientists discover axolotls regenerate a complete thymus from scratch, revealing midkine signaling as a key early driver with implications for reversing immune aging.
Researchers show that enhancing thymic epithelial cell activity in aged mice rebuilds naΓ―ve T-cell populations and dramatically improves survival after infection.
New research finds functional thymic tissue persists in adults over 50, with women and nonsmokers retaining significantly greater immune-generating capacity.
New Nature studies reveal the thymus remains a critical organ in adult health, predicting mortality, cardiovascular, and cancer outcomes.
Short-term rapamycin causes temporary thymic involution, then triggers regeneration exceeding baseline β hinting at immune rejuvenation as a longevity mechanism.
A massive single-cell study of 387,762 cells uncovers how thymic aging disrupts T cell development and reshapes peripheral immune function.
Review explores how thymosin alpha-1 could restore immune function by reversing thymic involution and reducing chronic inflammation in aging.
A deep mechanistic exploration of the signaling networks governing thymic involution and the most promising therapeutic strategies β from FOXN1 gene therapy to senolytics β entering clinical translation.
Go beyond the basics to explore the cellular and molecular machinery driving thymic involution β and the cutting-edge strategies researchers are using to reverse it.
Thymic mimetic cells emerge in two developmental waves, with FOXN1 driving postnatal tolerance to vertebrate-specific tissues like the liver.
Discover how a tiny gland in your chest quietly shapes your immune defenses β and what science is learning about turning back its clock.
A deep learning system measuring thymic health from CT scans reveals that better thymic function predicts longer life and lower cancer and heart disease risk.
New research reveals how baby mouse hearts retain regenerative immune cells by preventing their removal through lymphatic vessels.
A deep-learning analysis of 3,476 patients shows thymic health measured from routine CT scans strongly predicts immunotherapy outcomes across cancer types.
Scientists identify MRAP as a key molecular driver of thymic fat replacement, linking thymosin-Ξ±1 and FoxO1 signaling to immune aging.
Harvard researchers discovered how to restore full organ regeneration in mammalian skin by preventing excessive nerve growth.
