20 articles
A comprehensive review reveals the thymus retains stem-like epithelial progenitors into adulthood, challenging the idea it is immunologically expendable.
A landmark review reveals the molecular pathways driving thymic self-repair after injury, with major implications for aging immunity.
A detailed review of the cellular and molecular pathways driving thymic regeneration after acute damage, with implications for post-treatment immune recovery.
Scientists built a microwell-based mini-thymus that replicates native thymic biology and supports T cell development at scale.
A comprehensive review deconstructs the thymic microenvironment using single-cell technologies, from embryonic formation through age-related involution.
Harvard researchers identify a rare mesenchymal cell type that regenerates the thymus and boosts T cell immunity in aged animals.
Radioresistant intrathymic stem cells and a secreted growth factor called THGF may hold the key to thymic recovery after irradiation and cancer risk.
Scientists discover axolotls regenerate a complete thymus from scratch, revealing midkine signaling as a key early driver with implications for reversing immune aging.
Researchers show that enhancing thymic epithelial cell activity in aged mice rebuilds naΓ―ve T-cell populations and dramatically improves survival after infection.
Kyoto researchers built the first fully in vitro system that guides stem cells through every stage of human thymus development, producing functional T cells.
New research finds functional thymic tissue persists in adults over 50, with women and nonsmokers retaining significantly greater immune-generating capacity.
A newly discovered immune pathway suppresses thymic regeneration post-damage β and blocking IL-18 may restore it.
Short-term rapamycin causes temporary thymic involution, then triggers regeneration exceeding baseline β hinting at immune rejuvenation as a longevity mechanism.
A massive single-cell study of 387,762 cells uncovers how thymic aging disrupts T cell development and reshapes peripheral immune function.
Review explores how thymosin alpha-1 could restore immune function by reversing thymic involution and reducing chronic inflammation in aging.
Thymic mimetic cells emerge in two developmental waves, with FOXN1 driving postnatal tolerance to vertebrate-specific tissues like the liver.
A deep learning system measuring thymic health from CT scans reveals that better thymic function predicts longer life and lower cancer and heart disease risk.
A new in vitro study shows Thymosin Ξ±1 triggers dendritic cells to release IL-15, boosting CD8+ T cell killing and reducing HIV reservoir size.
New research reveals how baby mouse hearts retain regenerative immune cells by preventing their removal through lymphatic vessels.
A deep-learning analysis of 3,476 patients shows thymic health measured from routine CT scans strongly predicts immunotherapy outcomes across cancer types.
