34 articles
Small molecule AA-20 clears protein aggregates and lipid droplets, extending C. elegans lifespan through a novel mTOR-independent autophagy pathway.
Deleting HSP60 in astrocytes causes mitochondrial failure and cellular senescence, disrupting neuroregeneration via the S1P/truncated-BDNF pathway.
Go beyond probiotics and fiber — explore the cutting-edge science of fecal microbiota transplantation, engineered postbiotics, and how the gut orchestrates systemic aging through immune and neural circuits.
Go beyond antioxidant basics to explore how polyphenols hijack transcription factor networks, remodel chromatin, and what randomized trials actually show about aging biomarkers.
A comprehensive review reveals how SCFAs, bile acids, and tryptophan metabolites reshape the tumor immune microenvironment in GI cancers.
A leading aging researcher audits NMN, urolithin A, spermidine, and more — revealing what actually works and what falls short.
A quercetin, NR, urolithin A, and alpha-lipoic acid combination boosted remaining lifespan in aged mice by 33%, even on a Western diet.
Seragon's oral combo therapy SRN-901 outperforms rapamycin in mice, boosting lifespan and slashing frailty through multi-pathway aging intervention.
Comprehensive review reveals how cellular recycling process autophagy mediates benefits of diet, exercise, and longevity drugs across species.
Novel nanoparticle therapy targets sarcopenia by restoring mitochondrial function and enhancing muscle-immune cell communication.
New research reveals how cellular cleanup of damaged mitochondria determines whether injured nerves can regrow and recover function.
Study shows pomegranate compound urolithin A improves motor function in ALS mice by activating cellular cleanup of damaged mitochondria.
