20 articles
A newly identified enzyme links lactate metabolism to liver cancer progression, and a natural compound delivered via nanoparticles shows striking anti-tumor results.
Cambridge scientists engineer a nanoprobe that detects therapy-induced senescence non-invasively through a simple urine colorimetric test.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
New non-invasive urine protein test accurately predicts which biliary tract cancer patients will respond to immunotherapy treatment.
Scientists explore how exosomes in urine samples could revolutionize early cancer detection through simple, non-invasive testing.
Early PSMA upregulation after enzalutamide predicts shorter survival, but adding Lu-177-PSMA-617 improves outcomes in resistant prostate cancer.
High-level randomized evidence quantifies genitourinary toxicity burden over time following prostate radiotherapy, with direct implications for treatment decisions.
Researchers uncover how cancer cells evade ADC therapy by suppressing drug uptake — and identify a drug target to reverse resistance.
A next-gen RAS inhibitor called daraxonrasib targets KRAS-mutant cholangiocarcinoma, showing strong preclinical results and early clinical activity.
Ginsenoside Rh4 suppresses colorectal cancer by boosting Akkermansia muciniphila and elevating protective bile acid UDCA via FXR signaling.
A macrophage-derived metabolite rewires tumor metabolism and flips immune cells from tumor-promoting to tumor-fighting.
Orally bioavailable cyclin A/B RxL inhibitors exploit a cell-cycle vulnerability in small-cell lung cancer and other G1-S-checkpoint-deficient tumors.
New research reveals how bone marrow cells produce taurine that feeds leukemia stem cells, offering potential therapeutic targets.
A tryptophan-derived gut metabolite suppresses colorectal cancer by blocking a key glycolysis enzyme via STAT3 inhibition.
A newly discovered hepatic micropeptide suppresses liver cancer progression by jamming a key mitochondrial RNA processing complex.
Scientists discover how two microbes team up to accelerate colon cancer, but L-arginine may disrupt their deadly partnership.
New EUS techniques enable liquid biopsies, AI-assisted diagnosis, and personalized therapy testing for pancreatic and liver diseases.
Researchers develop monoclonal antibody that specifically inhibits heparanase, reducing tumor growth and metastasis in multiple cancer types.
Scientists discover ALPK1 receptor agonists trigger powerful anti-tumor immunity, offering new immunotherapy approach beyond current treatments.
Researchers discover how cancer cells use lysosomes to resist RNA polymerase inhibitors and develop combination strategies to overcome this resistance.
