LEF1 Transcription Factor Identified as Master Regulator of T Cell Stemness in Chronic Disease
Researchers discover LEF1 marks true self-renewing T cells in autoimmunity and chronic infection, opening new therapeutic targets.
274 articles in this topic
Researchers discover LEF1 marks true self-renewing T cells in autoimmunity and chronic infection, opening new therapeutic targets.
A massive viral gene library exposes hundreds of proteins that suppress immune detection — with major implications for infection, cancer, and aging.
Authors reply to commentary on a landmark NEJM trial combining ianalumab and eltrombopag for immune thrombocytopenia.
Five decades after Ebola's discovery, leading virologists assess what works, what fails, and what must change in global outbreak preparedness.
Researchers outline the critical knowledge gaps blocking effective response to Bundibugyo ebolavirus, a rare but lethal filovirus.
New research suggests latent HIV hides in more T cell types than known, reshaping strategies for an HIV cure.
A new naloxone nasal spray receives FDA approval, expanding access to life-saving opioid reversal treatment.
The WHO has issued landmark guidelines standardizing care for two of the world's deadliest viral hemorrhagic fevers.
Experts argue that finding new autoantibodies in encephalitis is yielding diminishing returns and call for a shift in research priorities.
A Nature Medicine commentary reviews the accelerating pipeline of Lassa fever countermeasures, signaling progress against a deadly viral hemorrhagic disease.
A 2025 review from Johns Hopkins outlines how to accurately diagnose complement-mediated TMA using functional assays and systematic testing.
A 205,000-person UK Biobank study finds the EAT-Lancet diet reduces RA risk, with omega-3s and anti-inflammatory metabolites driving one-third of the benefit.