Metabolic Health
Oral GLP-1 Pills Deliver Double-Digit Weight Loss in Major Phase-3 Trials
Two landmark NEJM trials show oral GLP-1 drugs achieve 11–14% weight loss, potentially eliminating the need for injections.
Research Paper
Jul 6, 2026 0
Diabetes
296 articles in this topic
Metabolic Health
Tirzepatide Cuts Meal Calories by 59% in Just 3 Weeks, Brain Scans Reveal Why
A phase 1 trial shows tirzepatide slashes ad libitum calorie intake by over 500 kcal at a single meal while blunting brain reward responses to junk food.
Research Paper
Jul 6, 2026 0
Metabolic Health
GLP-1 Drugs Show Promise for Sarcopenic Obesity But Carry Real Muscle-Loss Risk
A new review weighs the benefits and dangers of using GLP-1 and GIP/GLP-1 therapies in older adults with sarcopenic obesity.
Research Paper
Jul 6, 2026 0
Metabolic Health
Semaglutide Before and After Knee Replacement — First RCT Tests GLP-1 for Surgical Prep
A pilot RCT tests whether semaglutide can optimize obese patients before and after total knee arthroplasty, targeting a critical gap in perioperative care.
Research Paper
Jul 6, 2026 0
Metabolic Health
This Dietary Pattern Cuts Metabolic Syndrome Risk by 34 Percent
A large Chinese cohort study identifies a nutrient-dense eating pattern linked to significantly lower metabolic syndrome odds.
Research Paper
Jul 6, 2026 0
Metabolic Health
Semaglutide Slashes Eosinophil Counts in Real-World Study of 371 Adults
A new real-world study finds semaglutide significantly reduces blood eosinophil levels, with the strongest effect in non-obese individuals.
Research Paper
Jul 6, 2026 0
Metabolic Health
Ghrelin Is Far More Than a Hunger Hormone — Here Is What the Science Shows
A sweeping 2025 review reveals ghrelin's roles span immunity, neuroprotection, cardiovascular health, and addiction beyond appetite.
Research Paper
Jul 5, 2026 0
Metabolic Health
Blocking a Hunger Hormone Receptor in Macrophages Slows Liver Scarring
Deleting GHSR in macrophages cuts liver fibrosis markers and inflammation in mice, revealing a druggable signaling axis.
Research Paper
Jul 5, 2026 0
Metabolic Health
AMP Molecule Fights Sepsis Muscle Loss by Targeting AMPK and Inflammation
Adenosine 5'-monophosphate preserves muscle mass during sepsis by activating AMPK and blocking IL-1β, offering a potential new therapy.
Research Paper
Jul 5, 2026 0
Metabolic Health
Mass Cytometry Uncovers Hidden Immune Changes Before Type 1 Diabetes Strikes
Imaging 16 million pancreatic cells reveals macrophage-T cell interactions and beta-cell stress signatures at the earliest, preclinical stages of type 1 diabetes.
Research Paper
Jul 5, 2026 0
Metabolic Health
Pyruvate Directly Rewrites Your Epigenome When Blood Sugar Spikes
A new PTM called lysine pyruvylation links glycolytic activity directly to gene regulation, with SIRT3 acting as the eraser.
Research Paper
Jul 5, 2026 0
Metabolic Health
First GWAS of Metformin Blood Levels Reveals Age, Kidney Function, and Ancestry Shape Drug Exposure
A 745-person genomic study identifies why metformin concentrations vary so widely — with ancestry-specific genetic variants playing a key role.
Research Paper
Jul 4, 2026 0
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