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40 Hz Brain Stimulation Boosts Cognition in Alzheimer's PatientsBrain Health

40 Hz Brain Stimulation Boosts Cognition in Alzheimer's Patients

Researchers tested a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) at 40 Hz — the brain's gamma frequency — in patients with mild Alzheimer's disease. Over 15 consecutive days of 30-minute sessions targeting the parietal lobes, patients showed meaningful gains in global cognition, memory, language, attention, and executive function compared to a sham control group. Behavioral symptoms measured by neuropsychiatric inventory also improved significantly. Brain imaging revealed stronger connectivity within the default mode network and between key cognitive networks. EEG analysis showed improved information flow from temporal and prefrontal regions. Encouragingly, benefits appeared stable at a 10-week follow-up, suggesting the effects last beyond the treatment window. Researchers concluded that 40 Hz biparietal tACS is a safe, feasible, and potentially effective non-drug option for slowing cognitive decline in early Alzheimer's.

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