Longevity & AgingA New Framework for Measuring Immune Aging in Clinical Trials
The immune system touches every organ in the body, and its gradual decline with age is now thought to drive much of the systemic deterioration we associate with getting older. Yet clinical trials testing anti-aging interventions have lacked agreed-upon ways to measure immune aging. This review from researchers at Stanford, Harvard, and leading international institutions establishes a translational framework for selecting immune aging biomarkers. They define five evaluation criteria and apply them to a range of candidate measures, finding that multidimensional immune function metrics, inflammaging scores, and functional assays perform best. The work is partly shaped by the XPRIZE Healthspan competition and aims to give geroscience trials a coherent, clinically meaningful toolkit for quantifying immune fitness and resilience.
