Nutrition & DietBeta-Hydroxybutyrate May Outperform NAD+ as a Longevity Metabolite
This video examines beta-hydroxybutyrate (bHB), a ketone body produced during fasting or ketogenic eating, arguing it may surpass NAD+ as a longevity-relevant metabolic compound. Thomas DeLauer and Dr. Jacob Torres cover how bHB acts not just as fuel but as an epigenetic signal, influencing gene expression through a process called acylation. They discuss its anti-inflammatory properties, its role in gut barrier integrity, kidney health, and heart function. The conversation also explores practical protocols for people over 40, comparing intermittent ketosis versus exogenous ketone supplementation. Niacin's relationship with bHB and fat mobilization is also unpacked, along with why blood ketone meters may underreport tissue-level ketone activity.
