Longevity & Aging

Biological Aging Clocks Could Revolutionize Disease Prevention and Healthspan

Biological aging clocks are emerging tools that measure how fast a person — and their individual organs, tissues, and cells — is aging at the biological level, independent of chronological age. A major new review in Nature Medicine by Stanford's Tony Wyss-Coray and Scripps' Eric Topol critically assesses the state of these clocks, covering everything from epigenetic markers to protein-based measures. These clocks could soon enable clinicians to identify high-risk individuals before disease strikes, monitor whether interventions like senolytics or epigenetic reprogramming are actually slowing aging, and personalize prevention strategies. The authors argue that biological clocks represent a transformative shift in how we understand aging — moving from population-level statistics to individual-level biological reality.