Longevity & AgingBlood Protein Test Reveals Which Organs Age Fastest and Who Lives Longest
Researchers analyzed 2,916 blood proteins from 44,498 UK Biobank participants to estimate biological age across 11 organs. Brain and immune system aging emerged as the strongest predictors of longevity and disease risk. An accelerated brain age carried Alzheimer's disease risk comparable to carrying one APOE4 copy, while a youthful brain offered protection similar to two APOE2 copies. Having 8 or more aged organs increased mortality risk 8.3-fold, while individuals with both a youthful brain and immune system had 56% lower mortality risk. Organ age gaps were sensitive to lifestyle factors and medications, suggesting these biomarkers could be useful targets for monitoring and intervention.
