Longevity & AgingBlood Rejuvenation and Epigenetic Reset May Work Better Together Against Aging
Scientists have long debated whether aging is driven more by harmful factors circulating in the blood or by changes inside individual cells that alter how genes are read. A new review in Ageing Research Reviews argues the answer is both — and that combining two cutting-edge strategies could be more powerful than either alone. The first strategy, systemic recalibration, involves modifying the blood environment, from experimental parabiosis studies in animals to therapeutic plasma exchange in humans, to remove age-promoting factors. The second, partial cellular reprogramming, uses transient activation of Yamanaka factors to reset epigenetic marks inside cells without fully reverting them to stem-cell states. The review proposes an integrated framework and calls for mechanistic research and better biomarkers to evaluate combined approaches.
