Longevity & AgingBlood Sugar Molecules Called Glycans May Predict and Reverse Biological Aging
Researchers analyzing data from over 20,000 people across 42 studies found that tiny sugar molecules attached to immune antibodies — called IgG glycans — closely track biological aging and can predict risk of death independent of chronological age. More strikingly, these glycan patterns appear to shift in a more youthful direction in response to certain interventions. Caloric restriction, hormone replacement therapy, and therapeutic plasma exchange all showed effects, with plasma exchange producing the strongest change — roughly 0.4 years of glycan age reduction per month. Led by Professor Gordan Lauc of GlycanAge and the University of Zagreb, the research positions IgG glycans as both a measurable aging biomarker and a potential therapeutic target for extending healthspan.
