Longevity & AgingCircular RNA Telomerase Outperforms mRNA in Reversing Accelerated Aging in Progeria Cells
Researchers at Houston Methodist tested whether circular RNA encoding telomerase (TERT circRNA) could more effectively reverse cellular aging than linear TERT mRNA in endothelial cells derived from Hutchinson-Gilford Progeria Syndrome (HGPS) patients. Because circular RNAs lack free ends vulnerable to enzymatic degradation, they persist longer in cells. A single transfection of TERT circRNA outperformed mRNA across every measure tested: it extended telomeres more robustly, reduced senescence markers (β-galactosidase, p16, p21, progerin), lowered inflammatory cytokines (IL-1β, IL-6, IL-8), restored nitric oxide production and LDL uptake, improved angiogenesis, and normalized mitochondrial function. Crucially, benefits persisted 28 days post-transfection, whereas mRNA effects faded. This is reportedly the first therapeutic use of circular RNA to reverse senescence.
