Metabolic HealthDominic D'Agostino on Ketogenic Therapy, Ketone Supplements, and Hyperbaric Oxygen for Brain Injury
Researcher Dominic D'Agostino joins STEM-Talk to discuss his lab's latest work on ketogenic metabolic therapy (KMT), ketone supplementation safety, and hyperbaric oxygen therapy. KMT — a high-fat, very low-carb diet keeping carbs under 20–25 grams per day — is being explored as a complement to immune-based cancer treatments, especially for aggressive brain tumors like glioblastoma. D'Agostino also covers a rodent study showing that different ketone supplement formulations have strikingly different effects on liver health: ketone salts appear protective, while some ketone esters and precursors may drive liver inflammation and fatty changes. Additionally, a proposed orthomolecular protocol aims to simultaneously enhance mitochondrial function and cut off cancer's two primary fuel sources — glucose and glutamine — targeting both cancer stem cells and metastasis.
