Longevity & AgingFDA Warns Orlistat Weight-Loss Drug Linked to Kidney Stones and Acute Kidney Injury
The FDA has issued a safety alert requiring new kidney risk warnings on all orlistat products, including the OTC version Alli and prescription Xenical. After reviewing adverse event reports from 2007 to 2023, the agency identified 12 cases of kidney complications including acute kidney injury, oxalate nephropathy, and calcium oxalate kidney stones. Five patients required dialysis. The drug works by blocking fat absorption, but unabsorbed fats may increase oxalate absorption, potentially damaging kidneys. People with a history of kidney disease or kidney stones are advised to consult a doctor before using orlistat. Anyone experiencing back pain, blood in urine, or swelling in feet or legs should stop taking the drug immediately and seek medical attention.
