Longevity & AgingFive Drug Classes Show Promise for Extending Human Healthspan and Reversing Aging
This comprehensive review examines emerging pharmacological strategies for human anti-aging therapy, focusing on five key drug classes that target the nine hallmarks of aging. The authors analyze senolytics (like dasatinib and quercetin), senomorphics, NAD+ precursors, mTOR inhibitors, and metabolic modifiers including metformin. Early clinical trials show promise, with dasatinib plus quercetin reducing senescent cell burden in diabetic kidney disease patients and improving physical function. However, challenges remain including biomarker identification, safety concerns, and regulatory hurdles for translating promising preclinical results into clinical practice.
