Longevity & AgingGlyNAC Supplementation Plus Exercise May Reverse Key Hallmarks of Aging
This narrative review evaluates glycine, N-acetylcysteine (NAC), and their combination (GlyNAC) as nutritional strategies to combat aging-related decline. Both compounds are glutathione precursors that individually show promise for improving redox balance, mitochondrial function, and exercise performance—though with mixed results in healthy populations. When combined as GlyNAC, clinical and preclinical evidence shows improvements in oxidative stress, insulin resistance, inflammation, muscle strength, cognition, and even lifespan extension in animal models. The review also highlights exercise as a potent synergistic partner for GlyNAC, suggesting this combination may represent a novel, accessible approach to slowing functional decline, sarcopenia, and frailty in older adults, while calling for larger, well-designed trials to confirm findings.
