Longevity & AgingHeart Repair Gene SNHG15 Boosts Blood Vessel Growth After Heart Attack
Researchers identified a long non-coding RNA called SNHG15 that significantly improves heart repair after myocardial infarction by promoting angiogenesis (new blood vessel formation). Using mouse models, they found SNHG15 works by blocking miR-665, which allows increased expression of KDR, a key receptor for blood vessel growth. When SNHG15 was overexpressed in endothelial cells, it enhanced cardiac function, reduced scar size, and increased blood vessel density in damaged heart tissue. This discovery reveals a new therapeutic target for treating heart attacks and improving cardiac recovery.
