This clinical trial investigated whether combining estrogen with a weak androgen (DHEA) provides superior relief for psychological complaints and sexual dysfunction compared to estrogen-only therapy in postmenopausal women. The study enrolled 140 participants in a crossover design where women received both treatments in different sequences over 10 cycles. All participants with intact uteruses also received progesterone to prevent endometrial overgrowth. The research aimed to address the broader spectrum of menopausal symptoms beyond hot flashes, focusing specifically on mood, anxiety, depression, and sexual interest that significantly impact quality of life during menopause.
