Longevity & AgingHow Chronic Endometritis Hijacks the Immune System and What Doctors Can Do
Chronic endometritis (CE) is a persistent uterine inflammation strongly linked to infertility, recurrent pregnancy loss, and implantation failure. This 2025 review from China Medical University synthesizes how microbial dysbiosis triggers immune dysregulation via TLR/NLR signaling, NLRP3 inflammasome activation, immune cell metabolic reprogramming, miRNA-mediated inflammation, and DNA methylation changes. Standard antibiotic regimens like doxycycline improve outcomes for many patients, but treatment failures and antibiotic resistance remain serious obstacles. Probiotics and intrauterine therapies show emerging promise. The review calls for standardized diagnostics and mechanistically guided treatments to close persistent knowledge gaps.
