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How Chronic Inflammation Silently Rewires Your Brain and Drives DepressionGut & Microbiome

How Chronic Inflammation Silently Rewires Your Brain and Drives Depression

Chronic inflammation — driven by factors like poor gut health, gum disease, obesity, menopause, stress, and aging — may directly alter brain function and contribute to depression, anxiety, brain fog, and dementia risk. Professor Ed Bullmore of King's College London argues that medicine's separation of physical and mental health has obscured the true root causes of mood disorders. Emerging research suggests roughly 30% of severe depression cases may have an inflammatory origin, meaning standard antidepressants could be missing the mark entirely. Practical strategies covered include anti-inflammatory diet, targeted exercise, stress reduction, and oral health — all of which may reduce brain inflammation and improve mood outcomes.

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