Longevity & AgingHow PAI-1 Shapes Human Lifespan and What You Can Do About It
This video features Dr. Douglas Vaughan, a leading researcher on PAI-1 (plasminogen activator inhibitor-1), a protein increasingly linked to biological aging and lifespan in humans. PAI-1 is best known for its role in blood clotting, but emerging evidence suggests it also drives cellular senescence, metabolic decline, and age-related disease. Vaughan's research, including studies on Amish populations with PAI-1 gene mutations who live longer and have lower rates of diabetes, points to PAI-1 as a genuine longevity target. The conversation likely explores how elevated PAI-1 levels accelerate aging, what lifestyle or pharmacological interventions may lower it, and how this protein connects cardiovascular risk, metabolic health, and lifespan extension. This is highly relevant for anyone tracking biological age or cardiovascular biomarkers.
