Longevity & AgingHow Your APOE Gene Shapes Brain Cholesterol and Alzheimer's Risk
This episode explores how the brain manages its own cholesterol system — almost entirely separate from the rest of the body — and why that matters for Alzheimer's disease. Renowned lipidologist Tom Dayspring explains how the APOE gene, particularly the APOE4 variant, disrupts cholesterol transport in the brain, potentially accelerating amyloid and tau pathology linked to neurodegeneration. The conversation also reviews current evidence on statins, ezetimibe, omega-3 fatty acids, and an emerging drug called obicetrapib, examining whether these interventions help or harm brain health. For anyone tracking their lipid panel or concerned about cognitive decline, this episode offers rare depth on a topic most clinicians rarely address.
