Longevity & AgingLargest APOE4 Study Yet Tests If Healthy Habits Can Offset Alzheimer's Gene Risk
A new research partnership between Prema Cognition and the Phoenix Community is enrolling more than 3,000 carriers of the APOE4 gene — the strongest known genetic risk factor for late-onset Alzheimer's — in one of the largest observational studies of its kind. Participants will use PREMAZ, a digital cognitive assessment developed with the University of Cambridge Memory Lab, while also logging sleep, exercise, nutrition, and metabolic biomarkers over time. The goal is to determine how much lifestyle choices can modify inherited dementia risk before symptoms ever appear. The study represents a shift toward patient-led, real-world data collection and could position routine cognitive tracking alongside heart rate and glucose monitoring as everyday health metrics.
