Longevity & AgingLargest Plasma Glycome GWAS Uncovers Liver and Immune Disease Connections
Researchers conducted the largest genome-wide association study (GWAS) of plasma protein N-glycosylation in 10,000 individuals, identifying 16 novel genetic loci and 13 new candidate genes. Key discoveries included GCKR, TRIB1, HP, SERPINA1, and CFH — genes predominantly expressed in the liver and immune tissues. These findings double the number of known genetic loci influencing blood N-glycosylation and establish previously unrecognized genetic bridges between glycan regulation, metabolic liver diseases, and inflammatory response. By integrating glycomics, proteomics, transcriptomics, and genomics, the study provides a foundational resource for biomarker discovery and deeper understanding of glycan-related disease mechanisms.
