Longevity & AgingMultiomics Portrait of the World's Oldest Person Reveals Secrets of Extreme Longevity
Researchers performed a comprehensive multiomics analysis of M116, the world's oldest verified living person at 117 years old. By examining her genome, transcriptome, epigenome, metabolome, proteome, and microbiome against matched cohorts, the team identified a dual molecular signature: hallmarks of extreme aging including telomere shortening, clonal hematopoiesis, and abnormal B cell populations coexisted with protective features such as rare resilience-associated genetic variants, low systemic inflammation, a gut bacteriome resembling younger individuals, and an epigenetic clock reading younger than her chronological age. The findings suggest that exceptional longevity is not simply the absence of aging, but rather a balance between aging processes and biological resilience mechanisms.
