Longevity & AgingNucleotide Supplements Reverse Age-Related Muscle Loss in Accelerated-Aging Mice
Researchers fed senescence-accelerated SAMP8 mice a nucleotide (NT) mixture for 9–15 months and found significant improvements in lean mass, grip strength, gait speed, and muscle fiber cross-sectional area—particularly type IIb fibers. RNA sequencing revealed downregulation of sarcopenia-linked genes (Trim63, Fbxo32, Dkk3, Mt1, p53), while metabolomic analysis identified branched-chain amino acid metabolites that further inhibit protein degradation and promote synthesis. Cell studies in H₂O₂-stressed C2C12 myotubes confirmed these findings. The results suggest dietary nucleotides may act as a conditionally essential nutrient in older adults, offering a practical nutritional strategy against sarcopenia.
