Longevity & AgingPlant Compound Icariside II Fights Post-Stroke Depression via Gut-Brain Axis
Researchers found that Icariside II (ICS II), a natural flavonoid from the herb Epimedium, significantly reduced depression-like behaviors in a mouse model of post-stroke depression (PSD). Using MCAO combined with chronic stress, they showed ICS II directly binds and activates Sirt6, suppressing NF-κB-driven inflammation and oxidative stress in both brain and gut. ICS II also restored healthy gut microbiota composition—boosting Akkermansia and Ligilactobacillus—increased short-chain fatty acids, and repaired intestinal barrier integrity. Fecal microbiota transplants from ICS II-treated mice replicated antidepressant benefits in antibiotic-depleted recipients, confirming a causal gut microbiota role. Sirt6 knockout mice lost these protective effects, validating Sirt6 as the essential target.
