Longevity & AgingProteomics Reveals 8 AML Subtypes and an Aging Signature That Predicts Survival
Researchers at Shanghai's Ruijin Hospital analyzed proteome, phosphoproteome, genome, transcriptome, and drug-response data from 374 newly diagnosed AML patients. Using similarity network fusion clustering on over 10,000 proteins, they identified 8 distinct proteomic subtypes that align with and extend the current WHO classification of AML. They also discovered that megakaryocyte/platelet- and immune-related protein networks mark hematopoietic aging in AML. From these findings, they built a 19-protein Hematopoietic Aging Score (HAS) with independent prognostic value, where higher scores correlated with myelodysplasia-related AML, NPM1 mutations, and clonal hematopoiesis gene mutations—offering a new molecular lens on why AML is deadlier in older patients.
