Longevity & Aging

Senolytic Drug Combo Reverses Age-Related Bone Loss in Mice

Researchers tested whether dasatinib and quercetin (D+Q), a senolytic drug combination, could reverse age-related alveolar bone loss in mice. Aged mice showed increased bone resorption, thinner periodontal ligaments, and higher levels of senescent cells and inflammatory markers compared to young controls. Treatment with D+Q improved bone health by reducing the distance between tooth enamel and bone crest, enhancing periodontal ligament thickness, and balancing bone metabolism. The treatment also cleared senescent cells, reduced inflammatory signaling, and decreased neutrophil infiltration in aged bone tissue.